In the early-1990s, Luenell appeared regularly on Soul Beat TV on the Oakland, California cable station KSBT, along with prominent Bay Area African-American journalist Chauncey Bailey, an interviewer and talk show host on the program. Luenell was one of the few hired actors in the 2006 hit mockumentary comedy film Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan. In the film, Luenell plays a prostitute of the same name, a hooker with a heart of gold, who later marries Borat.

In 2012, she acted in three #1 feature films: Think Like A Man; the 3D animated hit Hotel Transylvania, with Adam Sandler; and Taken 2, with Liam Neeson. She also co-starred in the comedy That’s My Boy with Adam Sandler and Leighton Meester. TV appearances include episodes of The Middle and It’s Always Sunny In Philadelphia, as well as stand-up appearances on Snoop Dog’s Bad Girls of Comedy on Showtime and Stand-up In Stilettos on the TV Guide Network.

An interview and non-nude photo spread of Luenell appeared in the April 2017 issue of Penthouse magazine.